In particular, electrophysiological recordings in rodents suggest that HPC–VS projections might carry spatial information 14, 15. It has been hypothesized that each one of these distinct pathways relays specific information to the VS. The VS receives prominent glutamatergic projections from the prefrontal cortex, the amygdala and the HPC formation 10, 11, 12, 13. In line with these findings, it has been demonstrated that key molecular alterations, required for successful consolidation of newly acquired spatial information in the HPC, also occurs in the VS 9. Indeed VS post-training manipulations induce deficits in spatial memory tasks, suggesting the necessity of off-line neural activity within this brain region in order to consolidate spatial memories 5, 6, 7, 8. In this framework, neural activity in the ventral striatum (VS) has recently emerged as a fundamental event supporting spatial learning and memory consolidation. This view has recently evolved with the demonstration that memory consolidation depends upon the coordinated activity of the HPC and a network of brain regions including the neocortex and key subcortical structures 2, 3, 4. Established models describing stabilization of episodic memory suggest that the hippocampus (HPC) plays a crucial role in the early stages of memory consolidation (see ref.
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